Biotransformation of Xenobiotics and Hormones

Modulating Role of Panax Ginseng in Phase - II Reaction of Hepato - Biotransformation in Albino Rats Following Mercuric Chloride Intoxication

Introduction: The fate of xenobiotics that is present, increasing day by day. The increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. Methods: The present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by Panax ginse...

The role of biotransformation in the estrogenicity of xenobiotics The role of biotransformation in the estrogenicity of xenobiotics

Biotransformation of the toxic chemical substances

Free radicals and oxygen meatabolites by xenobiotics were studied. Reactive intermediates detoxification may be due to the hydrolysis, glutathione conjugation, or interactions with cellular antioxidants. When DNA is modified in biological systems or when isolated DNA, nucleosides, and nucleotides are reacted with the xenobiotic or its metabolites. Free radicals biotransformation was considered....

Biotransformation and induction: implications for toxicity, bioaccumulation and monitoring of environmental xenobiotics in fish.

Biotransformation of xenobiotics in fish occurs by many of the same reactions as in mammals. These reactions have been shown to affect the bioaccumulation, persistence, residue dynamics, and toxicity of select chemicals in fish. P-450-dependent monooxygenase activity of fish can be induced by polycyclic aromatic hydrocarbons, but phenobarbital-type agents induce poorly, if at all. Fish monooxyg...

Cytosolic sulfotransferases.

Sulfoconjugation (Sulfation or Sulfonation) is an important reaction in the phase II biotransformation of a wide number of endogenous and foreign chemicals, including: drugs, toxic chemicals, hormones, and neurotransmitters. The reaction is catalyzed by the members of the cytosolic sulfotransferase (SULT) superfamily, consisting of ten functional genes in humans. Sulfation reaction in living ce...